![]() ![]() The discovery of the drug artemisinin best illustrates the importance of CHM to the world ( Tu, 2016), inspiring the notion that, through study of their bioactive ingredients, CHMs can help people around the world to conquer life-threatening diseases. Therefore, in addition to the clinical applications mentioned in classic texts, understanding the specific active ingredients and clarifying the mechanisms of action of these compounds would facilitate the improved application of CHMs. notoginseng preparations are beneficial for patients with unstable angina pectoris ( Song et al., 2017).ĭespite the positive effects of CHMs, little is known about their effective constituents, bioactive ingredients, and mechanisms of action. A recent meta-analysis further demonstrated that several P. It is now commonly used in cases of trauma and cardiovascular, and cerebrovascular diseases. Chen, a traditional herb was initially used to stop bleeding, promote blood circulation and ease pain, was recorded in the Compendium of Materia Medica. was found to relieve abdominal pain and diarrhea and this herb is still widely used in China for the treatment of diarrhea or dysentery. For example, according to Sheng Nong's Herbal Classic, Coptis chinensis Franch. Most herbal medicines in such publications have been used constantly throughout medical history and are still applied in practice today. By the time of the Ming Dynasty (1368–1644), the number of CHMs listed in the book of Compendium of Materia Medica had increased to 1892. As early as the Qin and Han Dynasty (around 221 BCE to 220 CE), Sheng Nong's Herbal Classic recorded 365 medicines. Although research has been relatively limited and inadequate to date, the promising choices and new alternatives offered by bioactive ingredients for the treatment of the above diseases warrant serious investigation.Ĭhinese herbal medicines (CHMs) were the main treatment method used in ancient times by the Chinese to combat disease. Consequently, they have potential as treatment agents in diseases such as cancer, cardiovascular disease, nervous system disease, inflammatory bowel disease, asthma, infectious diseases, and senescence-related diseases. Here we review the evidence that, by regulating the expression of ncRNAs, these ingredients exert protective effects, including pro-apoptosis, anti-proliferation and anti-migration, anti-inflammation, anti-atherosclerosis, anti-infection, anti-senescence, and suppression of structural remodeling. The bioactive ingredients of some CHMs have been found to target various non-coding RNA molecules (ncRNAs), especially miRNAs, lncRNAs, and circRNAs, which have emerged as new treatment targets in numerous diseases. Since artemisinin was discovered to inhibit malaria by Nobel laureate Youyou Tu, extracts from natural plants, particularly bioactive ingredients, have aroused increasing attention among medical researchers. Bioactive ingredients are the main components extracted from herbs that have therapeutic properties. Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaĬhinese herbal medicines (CHMs) are widely used in China and have long been a powerful method to treat diseases in Chinese people.Yan Dong †, Hengwen Chen †, Jialiang Gao, Yongmei Liu, Jun Li * and Jie Wang *
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